Central nervous system regulation of adrenocorticotropin secretion: role of somatostatins
MR BROWN, C RIVIER, W VALE - Endocrinology, 1984 - academic.oup.com
MR BROWN, C RIVIER, W VALE
Endocrinology, 1984•academic.oup.comAbstract Somatostatin-28 (SS-28) and desAA1, 2, 4, 5, 12, 13 [dTrp8] somatostatin (ODT8-
SS), but not somatostatin-14, given intracerebroventricularly, but not when given iv, inhibit
stressinduced pituitary ACTH and adrenomedullary epinephrine secretion in rats. The
elevation of ACTH after tail-suspension stress is totally prevented by iv administration of
antisera raised against corticotropin-releasing factor (CRF). SS-28 and ODT8-SS do not
inhibit CRF-induced ACTH secretion in vivo or in vitro. These results are consistent with the …
SS), but not somatostatin-14, given intracerebroventricularly, but not when given iv, inhibit
stressinduced pituitary ACTH and adrenomedullary epinephrine secretion in rats. The
elevation of ACTH after tail-suspension stress is totally prevented by iv administration of
antisera raised against corticotropin-releasing factor (CRF). SS-28 and ODT8-SS do not
inhibit CRF-induced ACTH secretion in vivo or in vitro. These results are consistent with the …
Abstract
Somatostatin-28 (SS-28) and desAA1,2,4,5,12,13[dTrp8] somatostatin (ODT8-SS), but not somatostatin-14, given intracerebroventricularly, but not when given iv, inhibit stressinduced pituitary ACTH and adrenomedullary epinephrine secretion in rats. The elevation of ACTH after tail-suspension stress is totally prevented by iv administration of antisera raised against corticotropin-releasing factor (CRF). SS-28 and ODT8-SS do not inhibit CRF-induced ACTH secretion in vivo or in vitro. These results are consistent with the hypothesis that SS-28 and ODT8-SS prevent stress-induced ACTH secretion by inhibition of CRF release. (Endocrinology114: 1546, 1984)
Oxford University Press