The physiology of corticotropin-releasing hormone deficiency in mice
LJ Muglia, L Jacobson, SC Weninger, KP Karalis… - Peptides, 2001 - Elsevier
A review of the generation and characterization of corticotropin-releasing hormone (CRH)-
deficient mice is presented. The studies summarized demonstrate the central role of CRH in
the pituitary-adrenal axis response to stress, circadian stimulation, and glucocorticoid
withdrawal. Additionally, pro-inflammatory actions of CRH at sites of local inflammation are
given further support. In contrast, behavioral effects during stress that had been ascribed to
CRH action are not altered in CRH-deficient mice. The normal behavioral response to stress …
deficient mice is presented. The studies summarized demonstrate the central role of CRH in
the pituitary-adrenal axis response to stress, circadian stimulation, and glucocorticoid
withdrawal. Additionally, pro-inflammatory actions of CRH at sites of local inflammation are
given further support. In contrast, behavioral effects during stress that had been ascribed to
CRH action are not altered in CRH-deficient mice. The normal behavioral response to stress …