While aspects of cellular fatty acid uptake have been studied as early as 50 years ago,
recent developments in this rapidly evolving field have yielded new functional insights on
the individual mechanistic steps in this process. The extremely low aqueous solubility of
long chain fatty acids (LCFA) together with the very high affinity of serum albumin and
cytoplasmic fatty acid binding proteins for LCFA have challenged the limits of technology in
resolving the individual steps of this process. To date no single mechanism alone accounts …