[HTML][HTML] CD36 deficiency in mice impairs lipoprotein lipase-mediated triglyceride clearance
JR Goudriaan, MAM Den Boer, PCN Rensen… - Journal of lipid …, 2005 - ASBMB
CD36 is involved in high-affinity peripheral FFA uptake. CD36-deficient (cd36−/−) mice
exhibit increased plasma FFA and triglyceride (TG) levels. The aim of the present study was
to elucidate the cause of the increased plasma TG levels in cd36−/− mice. cd36−/− mice
showed no differences in hepatic VLDL-TG production or intestinal [3 H] TG uptake
compared with wild-type littermates. cd36−/− mice showed a 2-fold enhanced postprandial
TG response upon an intragastric fat load (P< 0.05), with a concomitant 2.5-fold increased …
exhibit increased plasma FFA and triglyceride (TG) levels. The aim of the present study was
to elucidate the cause of the increased plasma TG levels in cd36−/− mice. cd36−/− mice
showed no differences in hepatic VLDL-TG production or intestinal [3 H] TG uptake
compared with wild-type littermates. cd36−/− mice showed a 2-fold enhanced postprandial
TG response upon an intragastric fat load (P< 0.05), with a concomitant 2.5-fold increased …