[HTML][HTML] Fates of CD4+ T cells in a tolerant environment depend on timing and place of antigen exposure
BE Burrell, JS Bromberg - American Journal of Transplantation, 2012 - Elsevier
In experimental organ transplantation, tolerance is induced by administration of anti-CD40L
mAb in conjunction with donor-specific splenocyte transfusion. Multiple, sometimes
conflicting mechanisms of action resulting from this treatment have been reported. To
resolve these issues, this study assessed the fates of graft reactive cells at different times
and locations in the tolerant environment. Alloantigen-specific CD4+ T cells transferred at
time of tolerance induction (7 days before transplantation) became activated, expressed …
mAb in conjunction with donor-specific splenocyte transfusion. Multiple, sometimes
conflicting mechanisms of action resulting from this treatment have been reported. To
resolve these issues, this study assessed the fates of graft reactive cells at different times
and locations in the tolerant environment. Alloantigen-specific CD4+ T cells transferred at
time of tolerance induction (7 days before transplantation) became activated, expressed …