Importance Amyotrophic lateral sclerosis (ALS) has an immune component, but previous
human studies have not examined immune changes over time. Objectives To assess
peripheral inflammatory markers in participants with ALS and healthy control individuals and
to track immune changes in ALS and determine whether these changes correlate with
disease progression. Design, Setting, and Participants In this longitudinal cohort study,
leukocytes were isolated from peripheral blood samples from 35 controls and 119 …