Mast cells mediate neutrophil recruitment during atherosclerotic plaque progression
A Wezel, HM Lagraauw, D van der Velden… - Atherosclerosis, 2015 - Elsevier
Aims Activated mast cells have been identified in the intima and perivascular tissue of
human atherosclerotic plaques. As mast cells have been described to release a number of
chemokines that mediate leukocyte fluxes, we propose that activated mast cells may play a
pivotal role in leukocyte recruitment during atherosclerotic plaque progression. Methods and
results Systemic IgE-mediated mast cell activation in apoE−/− μMT mice resulted in an
increase in atherosclerotic lesion size as compared to control mice, and interestingly, the …
human atherosclerotic plaques. As mast cells have been described to release a number of
chemokines that mediate leukocyte fluxes, we propose that activated mast cells may play a
pivotal role in leukocyte recruitment during atherosclerotic plaque progression. Methods and
results Systemic IgE-mediated mast cell activation in apoE−/− μMT mice resulted in an
increase in atherosclerotic lesion size as compared to control mice, and interestingly, the …