[PDF][PDF] Purging the HIV-1 reservoir through the disruption of the PD-1 pathway
S Dafonseca, N Chomont, M El Far, R Boulassel… - J Int AIDS …, 2010 - researchgate.net
Diapositive 1 Page 1 Introduction Methods Conclusions Our results suggest that (i) PD-1 can
be used as a specific marker to target HIV-1 reservoir cells, (ii) viral production is inhibited
after triggering of the PD-1 receptor and (iii) viral production is enhanced after blocking of this
inhibitory pathway. Altogether, our results suggest a crucial role for PD-1 in the establishment
and maintenance of the HIV reservoir. PBMCs were obtained by leukapheresis from HAART
naïve chronically HIV-1 infected subjects and were subjected to CD4+T cells negative …
be used as a specific marker to target HIV-1 reservoir cells, (ii) viral production is inhibited
after triggering of the PD-1 receptor and (iii) viral production is enhanced after blocking of this
inhibitory pathway. Altogether, our results suggest a crucial role for PD-1 in the establishment
and maintenance of the HIV reservoir. PBMCs were obtained by leukapheresis from HAART
naïve chronically HIV-1 infected subjects and were subjected to CD4+T cells negative …