NF-κB/Rel: agonist and antagonist roles in HIV-1 latency
JKL Chan, WC Greene - Current Opinion in HIV and AIDS, 2011 - journals.lww.com
JKL Chan, WC Greene
Current Opinion in HIV and AIDS, 2011•journals.lww.comThese recent findings highlight both the antagonistic and agonistic effects of the NF-κB
signaling pathway on HIV-1 latency. Synergistic inducers might be useful for flushing of
latent virus from reservoirs in infected patients. The ultimate, albeit lofty, goal is to achieve
full viral eradication. However, a more reasonable goal might be a functional cure where
patients experience a drug-free remission.
signaling pathway on HIV-1 latency. Synergistic inducers might be useful for flushing of
latent virus from reservoirs in infected patients. The ultimate, albeit lofty, goal is to achieve
full viral eradication. However, a more reasonable goal might be a functional cure where
patients experience a drug-free remission.
Summary
These recent findings highlight both the antagonistic and agonistic effects of the NF-κB signaling pathway on HIV-1 latency. Synergistic inducers might be useful for flushing of latent virus from reservoirs in infected patients. The ultimate, albeit lofty, goal is to achieve full viral eradication. However, a more reasonable goal might be a functional cure where patients experience a drug-free remission.
Lippincott Williams & Wilkins