Effects of dichloroacetate on glycogen metabolism in B6C3F1 mice
J Kato-Weinstein, MK Lingohr, GA Orner, BD Thrall… - Toxicology, 1998 - Elsevier
Dichloroacetate (DCA) is a by-product of drinking water chlorination. Administration of DCA
in drinking water results in accumulation of glycogen in the liver of B6C3F1 mice. To
investigate the processes affecting liver glycogen accumulation, male B6C3F1 mice were
administered DCA in drinking water at levels varying from 0.1 to 3 g/l for up to 8 weeks. Liver
glycogen synthase (GS) and glycogen phosphorylase (GP) activities, liver glycogen content,
serum glucose and insulin levels were analyzed. To determine whether effects were primary …
in drinking water results in accumulation of glycogen in the liver of B6C3F1 mice. To
investigate the processes affecting liver glycogen accumulation, male B6C3F1 mice were
administered DCA in drinking water at levels varying from 0.1 to 3 g/l for up to 8 weeks. Liver
glycogen synthase (GS) and glycogen phosphorylase (GP) activities, liver glycogen content,
serum glucose and insulin levels were analyzed. To determine whether effects were primary …