[HTML][HTML] Nutrient and metabolic sensing in T cell responses
J Wei, J Raynor, TLM Nguyen, H Chi - Frontiers in immunology, 2017 - frontiersin.org
J Wei, J Raynor, TLM Nguyen, H Chi
Frontiers in immunology, 2017•frontiersin.orgT cells play pivotal roles in shaping host immune responses in infectious diseases,
autoimmunity, and cancer. The activation of T cells requires immune and growth factor-
derived signals. However, alterations in nutrients and metabolic signals tune T cell
responses by impinging upon T cell fates and immune functions. In this review, we
summarize how key nutrients, including glucose, amino acids, and lipids, and their sensors
and transporters shape T cell responses. We also briefly discuss regulation of T cell …
autoimmunity, and cancer. The activation of T cells requires immune and growth factor-
derived signals. However, alterations in nutrients and metabolic signals tune T cell
responses by impinging upon T cell fates and immune functions. In this review, we
summarize how key nutrients, including glucose, amino acids, and lipids, and their sensors
and transporters shape T cell responses. We also briefly discuss regulation of T cell …
T cells play pivotal roles in shaping host immune responses in infectious diseases, autoimmunity, and cancer. The activation of T cells requires immune and growth factor-derived signals. However, alterations in nutrients and metabolic signals tune T cell responses by impinging upon T cell fates and immune functions. In this review, we summarize how key nutrients, including glucose, amino acids, and lipids, and their sensors and transporters shape T cell responses. We also briefly discuss regulation of T cell responses by oxygen and energy sensing mechanisms.
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