[HTML][HTML] Pediatric autoimmune enteropathy: an entity frequently associated with immunodeficiency disorders
AD Singhi, A Goyal, JM Davison, MD Regueiro… - Modern Pathology, 2014 - Elsevier
The term pediatric autoimmune enteropathy was originally applied to a form of intractable
diarrhea seen in children under the age of 6 months and characterized by male
predominance, concurrent autoimmune-associated disorders, circulating gut autoantibodies,
a lack of severe immunodeficiency and small bowel atrophy with prominent crypt apoptosis.
However, recent studies have cast doubt over the specific clinicopathologic findings
associated with this entity. We, therefore, collected 178 gastrointestinal biopsies from 14 …
diarrhea seen in children under the age of 6 months and characterized by male
predominance, concurrent autoimmune-associated disorders, circulating gut autoantibodies,
a lack of severe immunodeficiency and small bowel atrophy with prominent crypt apoptosis.
However, recent studies have cast doubt over the specific clinicopathologic findings
associated with this entity. We, therefore, collected 178 gastrointestinal biopsies from 14 …