Administration of haptoglobin during cardiopulmonary bypass surgery
K TANAKA, Y KANAMORI, T SATO, C KONDO… - ASAIO …, 1991 - journals.lww.com
A study was undertaken to evaluate hemolysis and subsequent renal damage in 14 patients
undergoing cardiopulmonary bypass (CPB) surgery. In all patients, free haptoglobin
disappeared completely 30 to 90 minutes into CPB, while free hemoglobin (Hb) levels
increased progressively. The NAG index and [alpha] 1M index also increased progressively,
indicating renal tubular injury due to hemolysis (Study 1). An additional 20 patients were
monitored intraoperatively for plasma free Hb levels by a newly developed colorimetric …
undergoing cardiopulmonary bypass (CPB) surgery. In all patients, free haptoglobin
disappeared completely 30 to 90 minutes into CPB, while free hemoglobin (Hb) levels
increased progressively. The NAG index and [alpha] 1M index also increased progressively,
indicating renal tubular injury due to hemolysis (Study 1). An additional 20 patients were
monitored intraoperatively for plasma free Hb levels by a newly developed colorimetric …