Association between cell-free hemoglobin, acetaminophen, and mortality in patients with sepsis: an observational study
DR Janz, JA Bastarache, JF Peterson, G Sills… - Critical care …, 2013 - journals.lww.com
Objective: To determine the association of circulating cell-free hemoglobin with poor clinical
outcomes in patients with sepsis and to characterize the potential protective effects of
acetaminophen, an inhibitor of hemoprotein-mediated oxidation. Design: Retrospective
observational study. Patients: A total of 391 critically ill patients with sepsis in multiple ICUs
in an academic tertiary care hospital. Interventions: None. Measurements and Main Results:
Nonsurvivors had significantly higher plasma cell-free hemoglobin concentrations (median …
outcomes in patients with sepsis and to characterize the potential protective effects of
acetaminophen, an inhibitor of hemoprotein-mediated oxidation. Design: Retrospective
observational study. Patients: A total of 391 critically ill patients with sepsis in multiple ICUs
in an academic tertiary care hospital. Interventions: None. Measurements and Main Results:
Nonsurvivors had significantly higher plasma cell-free hemoglobin concentrations (median …