Plague bacillus: survival within host phagocytes

WA Janssen, MJ Surgalla - Science, 1969 - science.org
WA Janssen, MJ Surgalla
Science, 1969science.org
Pasteurella pestis within neutrophiles and macrophages removed from the peritoneal cavity
of guinea pigs during experimental plague were shown to be viable by direct microscopic
observation of the infected phagocytes incubating in suitable bacteriologic media. The time-
honored hypothesis that the major determinant of the virulence of the plague bacillus is its
ability to resist ingestion by phagocytes must be reevaluated.
Pasteurella pestis within neutrophiles and macrophages removed from the peritoneal cavity of guinea pigs during experimental plague were shown to be viable by direct microscopic observation of the infected phagocytes incubating in suitable bacteriologic media. The time-honored hypothesis that the major determinant of the virulence of the plague bacillus is its ability to resist ingestion by phagocytes must be reevaluated.
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