[HTML][HTML] Opposing roles for TRAF1 in the alternative versus classical NF-κB pathway in T cells
T cells lacking TRAF1 hyperproliferate in response to T cell receptor signaling but have
impaired signaling downstream of specific TNFR family members such as 4-1BB. Here we
resolve this paradox by showing that while TRAF1 is required for maximal activation of the
classical NF-κB pathway downstream of 4-1BB in primary T cells, TRAF1 also restricts the
constitutive activation of NIK in anti-CD3-activated T cells. Activation of the alternative NF-κB
pathway is restricted in unstimulated cells by a cIAP1/2: TRAF2: TRAF3: NIK complex. Using …
impaired signaling downstream of specific TNFR family members such as 4-1BB. Here we
resolve this paradox by showing that while TRAF1 is required for maximal activation of the
classical NF-κB pathway downstream of 4-1BB in primary T cells, TRAF1 also restricts the
constitutive activation of NIK in anti-CD3-activated T cells. Activation of the alternative NF-κB
pathway is restricted in unstimulated cells by a cIAP1/2: TRAF2: TRAF3: NIK complex. Using …
