Background: Upon activation, neutrophils can release nuclear material known as neutrophil
extracellular traps (NETs), which were initially described as a part of antimicrobial defense.
Extracellular chromatin was recently reported to be prothrombotic in vitro and to accumulate
in plasma and thrombi of baboons with experimental deep vein thrombosis (DVT). Objective:
To explore the source and role of extracellular chromatin in DVT. Methods: We used an
established murine model of DVT induced by flow restriction (stenosis) in the inferior vena …