[HTML][HTML] Cellular fibronectin binds to lysyl oxidase with high affinity and is critical for its proteolytic activation

B Fogelgren, N Polgár, KM Szauter, Z Ujfaludi… - Journal of Biological …, 2005 - ASBMB
Lysyl oxidase (LOX) is a copper-containing amine oxidase known to catalyze the covalent
cross-linking of fibrillar collagens and elastin at peptidyl lysine residues. In addition, its
involvement in cancer, wound healing, cell motility, chemotaxis, and differentiation reflect a
remarkable functional diversity of LOX. To investigate novel mechanisms of LOX regulation
and function, we performed a yeast two-hybrid screen to identify LOX-interacting proteins.
Three overlapping positive clones were identified as C-terminal fragments of fibronectin …