Tenascin-C and integrins in cancer
T Yoshida, T Akatsuka… - Cell adhesion & …, 2015 - Taylor & Francis
T Yoshida, T Akatsuka, K Imanaka-Yoshida
Cell adhesion & migration, 2015•Taylor & FrancisTenascin-C (TNC) is highly expressed in cancer tissues. Its cellular sources are cancer and
stromal cells, including fibroblasts/myofibroblasts, and also vascular cells. TNC expressed in
cancer tissues dominantly contains large splice variants. Deposition of the stroma promotes
the epithelial-mesenchymal transition, proliferation, and migration of cancer cells. It also
facilitates the formation of cancer stroma including desmoplasia and angiogenesis. Integrin
receptors that mediate the signals of TNC have also been discussed.
stromal cells, including fibroblasts/myofibroblasts, and also vascular cells. TNC expressed in
cancer tissues dominantly contains large splice variants. Deposition of the stroma promotes
the epithelial-mesenchymal transition, proliferation, and migration of cancer cells. It also
facilitates the formation of cancer stroma including desmoplasia and angiogenesis. Integrin
receptors that mediate the signals of TNC have also been discussed.
Tenascin-C (TNC) is highly expressed in cancer tissues. Its cellular sources are cancer and stromal cells, including fibroblasts/myofibroblasts, and also vascular cells. TNC expressed in cancer tissues dominantly contains large splice variants. Deposition of the stroma promotes the epithelial-mesenchymal transition, proliferation, and migration of cancer cells. It also facilitates the formation of cancer stroma including desmoplasia and angiogenesis. Integrin receptors that mediate the signals of TNC have also been discussed.
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