The role of promoter hypermethylation in fibroblast activation and fibrogenesis
EM Zeisberg, M Zeisberg - The Journal of pathology, 2013 - Wiley Online Library
EM Zeisberg, M Zeisberg
The Journal of pathology, 2013•Wiley Online LibraryThe aberrant methylation of CpG island promoters of selected genes is the prominent
epigenetic mechanism by which gene transcription can be effectively silenced. Aberrant
hypermethylation of a few selected genes plays an important role in facilitating fibrotic
fibroblast activation and in driving fibrogenesis. Here we review mechanisms of DNA
methylation and demethylation and their implications for fibroblast activation and tissue
fibrosis. Copyright© 2012 Pathological Society of Great Britain and Ireland. Published by …
epigenetic mechanism by which gene transcription can be effectively silenced. Aberrant
hypermethylation of a few selected genes plays an important role in facilitating fibrotic
fibroblast activation and in driving fibrogenesis. Here we review mechanisms of DNA
methylation and demethylation and their implications for fibroblast activation and tissue
fibrosis. Copyright© 2012 Pathological Society of Great Britain and Ireland. Published by …
Abstract
The aberrant methylation of CpG island promoters of selected genes is the prominent epigenetic mechanism by which gene transcription can be effectively silenced. Aberrant hypermethylation of a few selected genes plays an important role in facilitating fibrotic fibroblast activation and in driving fibrogenesis. Here we review mechanisms of DNA methylation and demethylation and their implications for fibroblast activation and tissue fibrosis.Copyright © 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
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