Podoplanin-positive cancer-associated fibroblasts could have prognostic value independent of cancer cell phenotype in stage I lung squamous cell carcinoma …
S Ono, G Ishii, K Nagai, T Takuwa, J Yoshida… - Chest, 2013 - Elsevier
Background The prognostic significance of the tumor microenvironment, which is created by
both cancer cells and cancer-associated fibroblasts (CAFs), has been increasingly
recognized. The purpose of this study was to analyze the prognostic markers of stage I
squamous cell carcinoma (SqCC), with special reference to the immunophenotypes of both
cancer cells and CAFs. Methods A total of 142 patients with stage I SqCC were included in
this study. We examined the expressions of E-cadherin, laminin-5, podoplanin, c-MET …
both cancer cells and cancer-associated fibroblasts (CAFs), has been increasingly
recognized. The purpose of this study was to analyze the prognostic markers of stage I
squamous cell carcinoma (SqCC), with special reference to the immunophenotypes of both
cancer cells and CAFs. Methods A total of 142 patients with stage I SqCC were included in
this study. We examined the expressions of E-cadherin, laminin-5, podoplanin, c-MET …