[HTML][HTML] Hyaluronan-CD44 interaction promotes c-Src-mediated twist signaling, microRNA-10b expression, and RhoA/RhoC up-regulation, leading to Rho-kinase …
LYW Bourguignon, G Wong, C Earle, K Krueger… - Journal of Biological …, 2010 - ASBMB
Dysregulation of microRNAs is observed in many cancers, including breast cancer. In
particular, miR-10b appears to play an important role in tumor cell invasion and breast
cancer progression. In this study, we investigated hyaluronan (HA)-induced CD44 (a primary
HA receptor) interaction with c-Src kinase and the transcriptional factor, Twist, in breast
tumor cells (MDA-MB-231 cells). Our results indicate that HA binding to CD44 promotes c-
Src kinase activation, which, in turn, increases Twist phosphorylation, leading to the nuclear …
particular, miR-10b appears to play an important role in tumor cell invasion and breast
cancer progression. In this study, we investigated hyaluronan (HA)-induced CD44 (a primary
HA receptor) interaction with c-Src kinase and the transcriptional factor, Twist, in breast
tumor cells (MDA-MB-231 cells). Our results indicate that HA binding to CD44 promotes c-
Src kinase activation, which, in turn, increases Twist phosphorylation, leading to the nuclear …