Transplantation of human spleen into immunodeficient NOD/SCID IL2Rγnull mice generates humanized mice that improve functional B cell development
YS Chung, JK Son, B Choi, JB Park, J Chang… - Clinical Immunology, 2015 - Elsevier
We previously generated humanized TB34N mice that received human fetal thymus (T),
bone tissue (B) and fetal liver-derived (FL)-CD34+ cells (34) in immunodeficient, NOD/SCID
IL2Rγ null (N) mice. Although humanized TB34N mice had excellent hematopoiesis, here,
we sought to further improve this model by additional transplantation of human spleen tissue
(S) as a secondary hematopoietic tissue (TBS34N). The human spleen grafts were enlarged
and differentiated into a similar morphology of adult humans, including follicular lymphoid …
bone tissue (B) and fetal liver-derived (FL)-CD34+ cells (34) in immunodeficient, NOD/SCID
IL2Rγ null (N) mice. Although humanized TB34N mice had excellent hematopoiesis, here,
we sought to further improve this model by additional transplantation of human spleen tissue
(S) as a secondary hematopoietic tissue (TBS34N). The human spleen grafts were enlarged
and differentiated into a similar morphology of adult humans, including follicular lymphoid …