The siRNA silencing approach has long been used as a method to regulate the expression
of specific target genes in vitro and in vivo. However, the effectiveness of delivery and the
nonspecific immune-stimulatory function of siRNA are the limiting factors for therapeutic
applications of siRNAs. To overcome these limitations, we developed self-assembled
micelle inhibitory RNA (SAMiRNA) nanoparticles made of individually biconjugated siRNAs
with a hydrophilic polymer and lipid on their ends and characterized their stability, immune …