N-acetylcysteine, coenzyme Q10 and superoxide dismutase mimetic prevent mitochondrial cell dysfunction and cell death induced by d-galactosamine in primary …
R González, G Ferrín, AB Hidalgo, I Ranchal… - Chemico-biological …, 2009 - Elsevier
d-Galactosamine (d-GalN) induces reactive oxygen species (ROS) generation and cell
death in cultured hepatocytes. The aim of the study was to evaluate the cytoprotective
properties of N-acetylcysteine (NAC), coenzyme Q10 (Q10) and the superoxide dismutase
(SOD) mimetic against the mitochondrial dysfunction and cell death in d-GalN-treated
hepatocytes. Hepatocytes were isolated from liver resections. NAC (0.5 mM), Q10 (30μM) or
MnTBAP (Mn (III) tetrakis (4-benzoic acid) porphyrin chloride (1mg/mL) were co …
death in cultured hepatocytes. The aim of the study was to evaluate the cytoprotective
properties of N-acetylcysteine (NAC), coenzyme Q10 (Q10) and the superoxide dismutase
(SOD) mimetic against the mitochondrial dysfunction and cell death in d-GalN-treated
hepatocytes. Hepatocytes were isolated from liver resections. NAC (0.5 mM), Q10 (30μM) or
MnTBAP (Mn (III) tetrakis (4-benzoic acid) porphyrin chloride (1mg/mL) were co …
