Increased poly (ADP-ribose) polymerase activity during porcine hemorrhagic shock is transient and predictive of mortality
DE Skarda, KS Putt, PJ Hergenrother, KE Mulier… - Resuscitation, 2007 - Elsevier
AIM OF THE STUDY: The aim of our study was to compare poly (ADP-ribose) polymerase
(PARP) activity levels in a porcine model of hemorrhagic shock and resuscitation.
MATERIALS AND METHODS: We designed a prospective, comparative randomized survival
study of hemorrhagic shock using 20 male Yorkshire–Landrace pigs (15–25kg). In 16 pigs
after splenectomy, we induced hemorrhagic shock to a mean arterial pressure of 50mm Hg
(∼ 35% bleed). Pigs were randomized to receive normotensive resuscitation (SBP 90mm …
(PARP) activity levels in a porcine model of hemorrhagic shock and resuscitation.
MATERIALS AND METHODS: We designed a prospective, comparative randomized survival
study of hemorrhagic shock using 20 male Yorkshire–Landrace pigs (15–25kg). In 16 pigs
after splenectomy, we induced hemorrhagic shock to a mean arterial pressure of 50mm Hg
(∼ 35% bleed). Pigs were randomized to receive normotensive resuscitation (SBP 90mm …
