[HTML][HTML] Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms
F Berger, C Lau, M Dahlmann, M Ziegler - Journal of Biological Chemistry, 2005 - ASBMB
Nicotinamide mononucleotide adenylyltransferase (NMNAT) is the central enzyme of the
NAD biosynthetic pathway. Three human NMNAT isoforms have recently been identified, but
isoform-specific functions are presently unknown, although a tissue-specific role has been
suggested. Analyses of the subcellular localization confirmed NMNAT1 to be a nuclear
protein, whereas NMNAT2 and-3 were localized to the Golgi complex and the mitochondria,
respectively. This differential subcellular localization points to an organelle-specific …
NAD biosynthetic pathway. Three human NMNAT isoforms have recently been identified, but
isoform-specific functions are presently unknown, although a tissue-specific role has been
suggested. Analyses of the subcellular localization confirmed NMNAT1 to be a nuclear
protein, whereas NMNAT2 and-3 were localized to the Golgi complex and the mitochondria,
respectively. This differential subcellular localization points to an organelle-specific …