Integration of signals mediated by B-cell receptor, B-cell activating factor of the tumor necrosis factor family (BAFF) and Fas (CD95)
The survival of the mature resting B cells depends on signaling from B cell receptor (BCR),
and a plethora of positive and negative regulators, that maintain cellular homeostasis and
ultimately determine cell's fate, ie, survival or programmed death (apoptosis). Among these
regulators we have investigated, besides the BCR, the effect of the B cell activating factor
belonging to tumor necrosis factor family (BAFF) and the prototypic death receptor
Fas/CD95. We have shown that BAFF inhibits Fas-mediated cell death, however, the BCR …
and a plethora of positive and negative regulators, that maintain cellular homeostasis and
ultimately determine cell's fate, ie, survival or programmed death (apoptosis). Among these
regulators we have investigated, besides the BCR, the effect of the B cell activating factor
belonging to tumor necrosis factor family (BAFF) and the prototypic death receptor
Fas/CD95. We have shown that BAFF inhibits Fas-mediated cell death, however, the BCR …