BAFF receptors and ligands create independent homeostatic niches for B cell subsets
MS Naradikian, AR Perate, MP Cancro - Current opinion in immunology, 2015 - Elsevier
MS Naradikian, AR Perate, MP Cancro
Current opinion in immunology, 2015•ElsevierHighlights•Systemic versus locally produced BAFF mediate distinct functions in homeostasis
and selection.•Differential expression of BAFF receptors defines independent homeostatic
niches.•BAFF family members play separate and independent roles in pre-immune, antigen
experienced, and innate B cell subsets.The BAFF family of receptors and ligands controls B
cell homeostasis and selection. Recent studies reveal distinct sources and roles for systemic
versus locally produced BAFF. Moreover, the notion that differential BAFF receptor …
and selection.•Differential expression of BAFF receptors defines independent homeostatic
niches.•BAFF family members play separate and independent roles in pre-immune, antigen
experienced, and innate B cell subsets.The BAFF family of receptors and ligands controls B
cell homeostasis and selection. Recent studies reveal distinct sources and roles for systemic
versus locally produced BAFF. Moreover, the notion that differential BAFF receptor …
Highlights
- Systemic versus locally produced BAFF mediate distinct functions in homeostasis and selection.
- Differential expression of BAFF receptors defines independent homeostatic niches.
- BAFF family members play separate and independent roles in pre-immune, antigen experienced, and innate B cell subsets.
The BAFF family of receptors and ligands controls B cell homeostasis and selection. Recent studies reveal distinct sources and roles for systemic versus locally produced BAFF. Moreover, the notion that differential BAFF receptor expression patterns establish independent homeostatic and selective niches has been strengthened. Finally, unique roles for BAFF family members in the regulation of antigen experienced and innate B cell subsets have been revealed. Herein, we overview current knowledge in these areas, emphasizing recent findings that inform these ideas.
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