BAFF and selection of autoreactive B cells
Z Liu, A Davidson - Trends in immunology, 2011 - cell.com
Z Liu, A Davidson
Trends in immunology, 2011•cell.comB cell activating factor (BAFF) is a crucial survival factor for transitional and mature B cells,
and is a promising therapeutic target for systemic lupus erythematosus (SLE). A BAFF
inhibitor, belimumab, is the first new drug in 50 years to be approved for the treatment of
SLE. However, the mechanism of action of this drug is not entirely clear. In this review we
will focus on the role of the BAFF–APRIL signaling pathway in the selection of autoreactive B
cells, and discuss whether altered selection is the mechanism for the therapeutic efficacy of …
and is a promising therapeutic target for systemic lupus erythematosus (SLE). A BAFF
inhibitor, belimumab, is the first new drug in 50 years to be approved for the treatment of
SLE. However, the mechanism of action of this drug is not entirely clear. In this review we
will focus on the role of the BAFF–APRIL signaling pathway in the selection of autoreactive B
cells, and discuss whether altered selection is the mechanism for the therapeutic efficacy of …
B cell activating factor (BAFF) is a crucial survival factor for transitional and mature B cells, and is a promising therapeutic target for systemic lupus erythematosus (SLE). A BAFF inhibitor, belimumab, is the first new drug in 50 years to be approved for the treatment of SLE. However, the mechanism of action of this drug is not entirely clear. In this review we will focus on the role of the BAFF–APRIL signaling pathway in the selection of autoreactive B cells, and discuss whether altered selection is the mechanism for the therapeutic efficacy of BAFF inhibition in SLE.
cell.com