[HTML][HTML] Identification of a new co-factor, MOG1, required for the full function of cardiac sodium channel Nav1. 5
L Wu, SL Yong, C Fan, Y Ni, S Yoo, T Zhang… - Journal of biological …, 2008 - ASBMB
The cardiac sodium channel Na v 1.5 is essential for the physiological function of the heart
and contributes to lethal cardiac arrhythmias and sudden death when mutated. Here, we
report that MOG1, a small protein that is highly conserved from yeast to humans, is a central
component of the channel complex and modulates the physiological function of Na v 1.5.
The yeast two-hybrid screen identified MOG1 as a new protein that interacts with the
cytoplasmic loop II (between transmembrane domains DII and DIII) of Na v 1.5. The …
and contributes to lethal cardiac arrhythmias and sudden death when mutated. Here, we
report that MOG1, a small protein that is highly conserved from yeast to humans, is a central
component of the channel complex and modulates the physiological function of Na v 1.5.
The yeast two-hybrid screen identified MOG1 as a new protein that interacts with the
cytoplasmic loop II (between transmembrane domains DII and DIII) of Na v 1.5. The …