[HTML][HTML] The reduction-insensitive bonds of the MUC2 mucin are isopeptide bonds

CV Recktenwald, GC Hansson - Journal of Biological Chemistry, 2016 - ASBMB
The main structural component of the mucus in the gastrointestinal tract is the MUC2 mucin.
It forms large networks that in colon build the loose outer mucous layer that provides the
habitat for the commensal flora and the inner mucous layer that protects the epithelial cells
by being impenetrable to bacteria. The epithelial cells in mice lacking MUC2 are not
adequately protected from bacteria, resulting in inflammation and the development of colon
cancer as found in human ulcerative colitis. Correct processing of the MUC2 mucin is the …