Airway inflammation in copd assessed by sputum levels of lnterleukin-8
C Yamamoto, T Yoneda, M Yoshikawa, A Fu… - Chest, 1997 - Elsevier
Study objective To assess the characteristics of airway inflammation in patients with COPD.
Methods We measured the sputum concentration of interleukin-8 (IL-8), a chemokine
involved in the migration and activation of neutrophils and eosinophils. We also measured
myeloperoxidase (MPO) as a parameter of neutrophil activity and eosinophil cationic protein
(ECP) as a parameter of eosinophil activity. Spontaneous sputum samples were obtained
from 33 patients with stable COPD and 30 patients with asthma. Induced sputum samples …
Methods We measured the sputum concentration of interleukin-8 (IL-8), a chemokine
involved in the migration and activation of neutrophils and eosinophils. We also measured
myeloperoxidase (MPO) as a parameter of neutrophil activity and eosinophil cationic protein
(ECP) as a parameter of eosinophil activity. Spontaneous sputum samples were obtained
from 33 patients with stable COPD and 30 patients with asthma. Induced sputum samples …