The relationship between glycated hemoglobin and polymorphonuclear leukocyte leukotriene B4 release in people with diabetes mellitus
C Parlapiano, C Danese, M Marangi… - Diabetes research and …, 1999 - Elsevier
C Parlapiano, C Danese, M Marangi, E Campana, P Pantone, T Giovanniello, E Zavattaro…
Diabetes research and clinical practice, 1999•ElsevierIn order to evaluate polymorphonuclear leukocyte (PMN) activity in diabetes mellitus,
leukotriene B4 (LTB4) levels were measured in sixty patients, 31 affected with Type 1
diabetes mellitus and 29 affected with Type 2 diabetes mellitus. The LTB4 levels (12.1+ 0.2
pg/100 μl) in diabetic patients were higher compared to those of the control group (7.9+ 0.1
pg/100 μl)(P< 0.001), and remained significantly higher (P< 0.001)(12.8+ 0.2 pg/100 μl) than
in the control group (11.0+ 0.2 pg/100 μ1) after stimulation with calcium ionophore. A …
leukotriene B4 (LTB4) levels were measured in sixty patients, 31 affected with Type 1
diabetes mellitus and 29 affected with Type 2 diabetes mellitus. The LTB4 levels (12.1+ 0.2
pg/100 μl) in diabetic patients were higher compared to those of the control group (7.9+ 0.1
pg/100 μl)(P< 0.001), and remained significantly higher (P< 0.001)(12.8+ 0.2 pg/100 μl) than
in the control group (11.0+ 0.2 pg/100 μ1) after stimulation with calcium ionophore. A …
In order to evaluate polymorphonuclear leukocyte (PMN) activity in diabetes mellitus, leukotriene B4 (LTB4) levels were measured in sixty patients, 31 affected with Type 1 diabetes mellitus and 29 affected with Type 2 diabetes mellitus. The LTB4 levels (12.1+0.2 pg/100 μl) in diabetic patients were higher compared to those of the control group (7.9+0.1 pg/100 μl) (P<0.001), and remained significantly higher (P<0.001) (12.8+0.2 pg/100 μl) than in the control group (11.0+0.2 pg/100 μ1) after stimulation with calcium ionophore. A significant and positive correlation between glycated hemoglobin and LTB4 was demonstrated (P<0.001, r=0.80). This study demonstrates that in diabetic patients there is a PMN activation and that this activation is correlated to glycated hemoglobin level.
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