[HTML][HTML] Rapamycin increases CCN2 expression of lung fibroblasts via phosphoinositide 3-kinase
X Xu, H Dai, J Geng, X Wan, X Huang, F Li… - Laboratory …, 2015 - Elsevier
Excessive production of connective tissue growth factor (CTGF, CCN2) and increased motor
ability of the activated fibroblast phenotype contribute to the pathogenesis of idiopathic
pulmonary fibrosis (IPF). However, molecules and signal pathways regulating CCN2
expression and migration of lung fibroblasts are still elusive. We hypothesize that rapamycin,
via binding and blocking mammalian target of rapamycin (mTOR) complex (mTORC), affects
CCN2 expression and migration of lung fibroblasts in vitro. Primary normal and fibrotic …
ability of the activated fibroblast phenotype contribute to the pathogenesis of idiopathic
pulmonary fibrosis (IPF). However, molecules and signal pathways regulating CCN2
expression and migration of lung fibroblasts are still elusive. We hypothesize that rapamycin,
via binding and blocking mammalian target of rapamycin (mTOR) complex (mTORC), affects
CCN2 expression and migration of lung fibroblasts in vitro. Primary normal and fibrotic …