[HTML][HTML] MEG3 long noncoding RNA contributes to the epigenetic regulation of epithelial-mesenchymal transition in lung cancer cell lines
M Terashima, S Tange, A Ishimura, T Suzuki - Journal of Biological …, 2017 - ASBMB
Histone methylation is implicated in a number of biological and pathological processes,
including cancer development. In this study, we investigated the molecular mechanism for
the recruitment of Polycomb repressive complex-2 (PRC2) and its accessory component,
JARID2, to chromatin, which regulates methylation of lysine 27 of histone H3 (H3K27),
during epithelial-mesenchymal transition (EMT) of cancer cells. The expression of MEG3
long noncoding RNA (lncRNA), which could interact with JARID2, was clearly increased …
including cancer development. In this study, we investigated the molecular mechanism for
the recruitment of Polycomb repressive complex-2 (PRC2) and its accessory component,
JARID2, to chromatin, which regulates methylation of lysine 27 of histone H3 (H3K27),
during epithelial-mesenchymal transition (EMT) of cancer cells. The expression of MEG3
long noncoding RNA (lncRNA), which could interact with JARID2, was clearly increased …