Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis
Y Zhang, F Vasheghani, Y Li, M Blati, K Simeone… - Annals of the rheumatic …, 2015 - Elsevier
Objectives Mammalian target of rapamycin (mTOR)(a serine/threonine protein kinase) is a
major repressor of autophagy, a cell survival mechanism. The specific in vivo mechanism of
mTOR signalling in OA pathophysiology is not fully characterised. We determined the
expression of mTOR and known autophagy genes in human OA cartilage as well as mouse
and dog models of experimental OA. We created cartilage-specific mTOR knockout (KO)
mice to determine the specific role of mTOR in OA pathophysiology and autophagy …
major repressor of autophagy, a cell survival mechanism. The specific in vivo mechanism of
mTOR signalling in OA pathophysiology is not fully characterised. We determined the
expression of mTOR and known autophagy genes in human OA cartilage as well as mouse
and dog models of experimental OA. We created cartilage-specific mTOR knockout (KO)
mice to determine the specific role of mTOR in OA pathophysiology and autophagy …
