Final results of a phase I–II trial using ex vivo expanded autologous mesenchymal stromal cells for the treatment of osteoarthritis of the knee confirming safety and …
R Soler, L Orozco, A Munar, M Huguet, R López… - The Knee, 2016 - Elsevier
Background Cellular therapies have shown encouraging results in the treatment of chronic
osteoarthritis (OA). Herein, we present the final results of a phase I–II clinical trial assessing
the feasibility, safety and efficacy of ex vivo expanded autologous bone marrow
Mesenchymal Stromal Cells (MSC, XCEL-M-ALPHA), infused intra-articularly, in patients
with knee OA. Methods Fifteen patients (median age= 52 years) with grade II (9) or III (6)
gonarthrosis (Kellgren & Lawrence classification) and chronic pain were treated with an intra …
osteoarthritis (OA). Herein, we present the final results of a phase I–II clinical trial assessing
the feasibility, safety and efficacy of ex vivo expanded autologous bone marrow
Mesenchymal Stromal Cells (MSC, XCEL-M-ALPHA), infused intra-articularly, in patients
with knee OA. Methods Fifteen patients (median age= 52 years) with grade II (9) or III (6)
gonarthrosis (Kellgren & Lawrence classification) and chronic pain were treated with an intra …