Arthroscopic transplantation of synovial stem cells improves clinical outcomes in knees with cartilage defects
I Sekiya, T Muneta, M Horie, H Koga - Clinical Orthopaedics and …, 2015 - journals.lww.com
I Sekiya, T Muneta, M Horie, H Koga
Clinical Orthopaedics and Related Research®, 2015•journals.lww.comBackground Transplantation of mesenchymal stem cells (MSCs) is one possible strategy to
achieve articular cartilage repair. We previously reported that synovial MSCs were highly
proliferative and able to undergo chondrogenesis. We also found that placing a suspension
of synovial MSCs on a cartilage defect for 10 minutes promoted cartilage repair in rabbit and
pig models. However, the in vivo efficacy of this approach has not been tested clinically.
achieve articular cartilage repair. We previously reported that synovial MSCs were highly
proliferative and able to undergo chondrogenesis. We also found that placing a suspension
of synovial MSCs on a cartilage defect for 10 minutes promoted cartilage repair in rabbit and
pig models. However, the in vivo efficacy of this approach has not been tested clinically.
Abstract
Background
Transplantation of mesenchymal stem cells (MSCs) is one possible strategy to achieve articular cartilage repair. We previously reported that synovial MSCs were highly proliferative and able to undergo chondrogenesis. We also found that placing a suspension of synovial MSCs on a cartilage defect for 10 minutes promoted cartilage repair in rabbit and pig models. However, the in vivo efficacy of this approach has not been tested clinically.
Lippincott Williams & Wilkins