[PDF][PDF] TGF-b signaling in cartilage homeostasis and osteoarthritis

KW Finnson, Y Chi, G Bou-Gharios, A Leask… - Front Biosci (Schol …, 2012 - academia.edu
KW Finnson, Y Chi, G Bou-Gharios, A Leask, A Philip
Front Biosci (Schol Ed), 2012academia.edu
Introduction 3. Overview of TGF-β signaling 3.1. TGF-β family 3.2. TGF-β synthesis and
activation of latent TGF-β 3.3. TGF-β receptors and signaling pathways 3.4. Regulation of
TGF-β signaling 3.4. 1. Extracellular control 3.4. 2. Intracellular control 4. TGF-β action in
cartilage 5. Deregulation of TGF-β signaling in osteoarthritis 5.1. TGF-β isoform expression
5.2. TGF-β activation 5.3. TGF-β receptor expression 5.4. Smad2/3 signaling 5.5. Smad1/5
signaling 5.6. Smad7/Smurf2 activity 5.7. Non-Smad pathways 5.8. TGF-β co-receptors 6 …
Abstract
Introduction 3. Overview of TGF-β signaling 3.1. TGF-β family 3.2. TGF-β synthesis and activation of latent TGF-β 3.3. TGF-β receptors and signaling pathways 3.4. Regulation of TGF-β signaling 3.4. 1. Extracellular control 3.4. 2. Intracellular control 4. TGF-β action in cartilage 5. Deregulation of TGF-β signaling in osteoarthritis 5.1. TGF-β isoform expression 5.2. TGF-β activation 5.3. TGF-β receptor expression 5.4. Smad2/3 signaling 5.5. Smad1/5 signaling 5.6. Smad7/Smurf2 activity 5.7. Non-Smad pathways 5.8. TGF-β co-receptors 6. TGF-β signaling pathway as a therapeutic target for osteoarthritis 7. Concluding remarks
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