missMethyl: an R package for analyzing data from Illumina's HumanMethylation450 platform
Bioinformatics, 2015•academic.oup.com
DNA methylation is one of the most commonly studied epigenetic modifications due to its
role in both disease and development. The Illumina HumanMethylation450 BeadChip is a
cost-effective way to profile> 450 000 CpGs across the human genome, making it a popular
platform for profiling DNA methylation. Here we introduce missMethyl, an R package with a
suite of tools for performing normalization, removal of unwanted variation in differential
methylation analysis, differential variability testing and gene set analysis for the 450K array …
role in both disease and development. The Illumina HumanMethylation450 BeadChip is a
cost-effective way to profile> 450 000 CpGs across the human genome, making it a popular
platform for profiling DNA methylation. Here we introduce missMethyl, an R package with a
suite of tools for performing normalization, removal of unwanted variation in differential
methylation analysis, differential variability testing and gene set analysis for the 450K array …
Abstract
Summary: DNA methylation is one of the most commonly studied epigenetic modifications due to its role in both disease and development. The Illumina HumanMethylation450 BeadChip is a cost-effective way to profile >450 000 CpGs across the human genome, making it a popular platform for profiling DNA methylation. Here we introduce missMethyl, an R package with a suite of tools for performing normalization, removal of unwanted variation in differential methylation analysis, differential variability testing and gene set analysis for the 450K array.
Availability and implementation: missMethyl is an R package available from the Bioconductor project at www.bioconductor.org.
Contact: alicia.oshlack@mcri.edu.au
Supplementary information: Supplementary data are available at Bioinformatics online.
Oxford University Press