Hyper-IgE syndrome (HIES) is a rare multisystem disorder with both immunologic and
nonimmunological features. It is characterized by extremely elevated IgE serum levels,
eczema, and recurrent skin and pulmonary infections. Dental anomalies are often included,
such as retention of deciduous teeth together with ectopic eruption or noneruption of
permanent teeth. Severe susceptibility to caries and mycotic infections, insufficient
transversal diameter of the palate, mucosal plaques, and fissures typically located on the …