[PDF][PDF] Intestinal interleukin-17 receptor signaling mediates reciprocal control of the gut microbiota and autoimmune inflammation

P Kumar, L Monin, P Castillo, W Elsegeiny, W Horne… - Immunity, 2016 - cell.com
P Kumar, L Monin, P Castillo, W Elsegeiny, W Horne, T Eddens, A Vikram, M Good
Immunity, 2016cell.com
Summary Interleukin-17 (IL-17) and IL-17 receptor (IL-17R) signaling are essential for
regulating mucosal host defense against many invading pathogens. Commensal bacteria,
especially segmented filamentous bacteria (SFB), are a crucial factor that drives T helper 17
(Th17) cell development in the gastrointestinal tract. In this study, we demonstrate that Th17
cells controlled SFB burden. Disruption of IL-17R signaling in the enteric epithelium resulted
in SFB dysbiosis due to reduced expression of α-defensins, Pigr, and Nox1. When subjected …
Summary
Interleukin-17 (IL-17) and IL-17 receptor (IL-17R) signaling are essential for regulating mucosal host defense against many invading pathogens. Commensal bacteria, especially segmented filamentous bacteria (SFB), are a crucial factor that drives T helper 17 (Th17) cell development in the gastrointestinal tract. In this study, we demonstrate that Th17 cells controlled SFB burden. Disruption of IL-17R signaling in the enteric epithelium resulted in SFB dysbiosis due to reduced expression of α-defensins, Pigr, and Nox1. When subjected to experimental autoimmune encephalomyelitis, IL-17R-signaling-deficient mice demonstrated earlier disease onset and worsened severity that was associated with increased intestinal Csf2 expression and elevated systemic GM-CSF cytokine concentrations. Conditional deletion of IL-17R in the enteric epithelium demonstrated that there was a reciprocal relationship between the gut microbiota and enteric IL-17R signaling that controlled dysbiosis, constrained Th17 cell development, and regulated the susceptibility to autoimmune inflammation.
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