Oropharyngeal candidiasis (OPC, thrush) is an opportunistic infection caused by the
commensal fungus Candida albicans. An understanding of immunity to Candida has
recently begun to unfold with the identification of fungal pattern-recognition receptors such
as C-type lectin receptors, which trigger protective T-helper (Th) 17 responses in the
mucosa. Hyper-IgE syndrome (HIES/Job's syndrome) is a rare congenital immunodeficiency
characterized by dominant-negative mutations in signal transducer and activator of …