Mechanisms of tissue injury in sepsis: contrasts between gram positive and gram negative infection
J Cohen - Journal of Chemotherapy, 2001 - Taylor & Francis
J Cohen
Journal of Chemotherapy, 2001•Taylor & FrancisSepsis is the systemic response to infection, and is caused by Gram positive and Gram
negative bacteria in approximately equal numbers. In recent years it has become
increasingly clear that there are significant differences between sepsis caused by Gram
positive and Gram negative infections, both in the microbial components that initiate the
injury, and the host responses that follow it. These differences will assume greater
importance in developing targeted therapeutic interventions to severe sepsis.
negative bacteria in approximately equal numbers. In recent years it has become
increasingly clear that there are significant differences between sepsis caused by Gram
positive and Gram negative infections, both in the microbial components that initiate the
injury, and the host responses that follow it. These differences will assume greater
importance in developing targeted therapeutic interventions to severe sepsis.
Abstract
Sepsis is the systemic response to infection, and is caused by Gram positive and Gram negative bacteria in approximately equal numbers. In recent years it has become increasingly clear that there are significant differences between sepsis caused by Gram positive and Gram negative infections, both in the microbial components that initiate the injury, and the host responses that follow it. These differences will assume greater importance in developing targeted therapeutic interventions to severe sepsis.
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