[HTML][HTML] Photoreceptor proteins initiate microglial activation via Toll-like receptor 4 in retinal degeneration mediated by all-trans-retinal

H Kohno, Y Chen, BM Kevany, E Pearlman… - Journal of Biological …, 2013 - ASBMB
Although several genetic and biochemical factors are associated with the pathogenesis of
retinal degeneration, it has yet to be determined how these different impairments can cause
similar degenerative phenotypes. Here, we report microglial/macrophage activation in both
a Stargardt disease and age-related macular degeneration mouse model caused by
delayed clearance of all-trans-retinal from the retina, and in a retinitis pigmentosa mouse
model with impaired retinal pigment epithelium (RPE) phagocytosis. Mouse microglia …