Obesity is a highly heritable trait. While acute and chronic changes in body weight or obesity-
related comorbidities are heavily influenced by environmental factors, there are still strong
genomic modifiers that help account for inter-subject variability in baseline traits and in
response to interventions. This review is intended to provide an up-to-date overview of our
current understanding of genetic influences on obesity, with emphasis on genetic modifiers
of baseline traits and responses to intervention. We begin by reviewing how genetic variants …