[HTML][HTML] Macropinocytosis exploitation by cancers and cancer therapeutics
KD Ha, SM Bidlingmaier, B Liu - Frontiers in physiology, 2016 - frontiersin.org
KD Ha, SM Bidlingmaier, B Liu
Frontiers in physiology, 2016•frontiersin.orgMacropinocytosis has long been known as a primary method for cellular intake of fluid-
phase and membrane-bound bulk cargo. This review seeks to re-examine the latest studies
to emphasize how cancers exploit macropinocytosis to further their tumorigenesis, including
details in how macropinocytosis can be adapted to serve diverse functions. Furthermore, this
review will also cover the latest endeavors in targeting macropinocytosis as an avenue for
novel therapeutics.
phase and membrane-bound bulk cargo. This review seeks to re-examine the latest studies
to emphasize how cancers exploit macropinocytosis to further their tumorigenesis, including
details in how macropinocytosis can be adapted to serve diverse functions. Furthermore, this
review will also cover the latest endeavors in targeting macropinocytosis as an avenue for
novel therapeutics.
Macropinocytosis has long been known as a primary method for cellular intake of fluid-phase and membrane-bound bulk cargo. This review seeks to re-examine the latest studies to emphasize how cancers exploit macropinocytosis to further their tumorigenesis, including details in how macropinocytosis can be adapted to serve diverse functions. Furthermore, this review will also cover the latest endeavors in targeting macropinocytosis as an avenue for novel therapeutics.
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