[HTML][HTML] Ligand binding determines whether CD46 is internalized by clathrin-coated pits or macropinocytosis
B Crimeen-Irwin, S Ellis, D Christiansen… - Journal of Biological …, 2003 - ASBMB
CD46 is a ubiquitous human cell surface receptor for the complement components C3b and
C4b and for various pathogens, including the measles virus and human herpes virus 6.
Ligand binding to CD46 affects (i) protection of autologous cells from complement attack by
breakdown of complement components,(ii) intracellular signals that affect the regulation of
immune cell function,(iii) antigen presentation, and (iv) down-regulation of cell surface
CD46. Recent evidence indicates that CD46 signaling can link innate and acquired immune …
C4b and for various pathogens, including the measles virus and human herpes virus 6.
Ligand binding to CD46 affects (i) protection of autologous cells from complement attack by
breakdown of complement components,(ii) intracellular signals that affect the regulation of
immune cell function,(iii) antigen presentation, and (iv) down-regulation of cell surface
CD46. Recent evidence indicates that CD46 signaling can link innate and acquired immune …