Atypical clinical behavior of p16-confirmed HPV-related oropharyngeal squamous cell carcinoma treated with radical radiotherapy
PURPOSE: To report atypical clinical behavior observed in human papillomavirus (HPV)–
related oropharyngeal carcinoma (OPC) treated with radiotherapy. METHODS AND
MATERIALS: A retrospective cohort study was conducted for all newly diagnosed OPC
cases treated with radiotherapy on July 1, 2003 to April 30, 2009. HPV positivity was
determined by p16 immunostaining in tumors. The incidence of additional malignancies and
the pattern of distant metastases (DMs) were compared between the HPV-positive (HPV+) …
related oropharyngeal carcinoma (OPC) treated with radiotherapy. METHODS AND
MATERIALS: A retrospective cohort study was conducted for all newly diagnosed OPC
cases treated with radiotherapy on July 1, 2003 to April 30, 2009. HPV positivity was
determined by p16 immunostaining in tumors. The incidence of additional malignancies and
the pattern of distant metastases (DMs) were compared between the HPV-positive (HPV+) …